November 5, 2018 Adi Hoess, Ph.D., M.D. Chief Executive Officer Affimed N.V. Technologiepark Im Neuenheimer Feld 582 69120 Heidelberg, Germany Re: Affimed N.V. Registration Statement on Form F-3 Filed October 22, 2018 File No. 333-227933 Dear Dr. Hoess: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Christine Westbrook at 202-551-5019 with any questions. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance cc: Derek Dostal, Esq.